Energetic depression caused by mitochondrial dysfunction.

Frank Norbert Gellerich; Sonata Trumbeckaite; Ying Chen; Marcus Deschauer; Tobias M ller; Stephan Zierz

PubMed · 12517722

Energetic depression caused by mitochondrial dysfunction.

Frank Norbert Gellerich·Sonata Trumbeckaite·Ying Chen·Marcus Deschauer·Tobias M ller·Stephan Zierz

Abstract

Mitochondria not only provide most of the ATP needed for cell work and numerous specific anabolic and catabolic functions, they also contribute to Ca++ signalling and play a key role in the pathway to cell death. Impairment of mitochondrial functions caused by mutations of the mt-genome or by acute processes, is responsible for numerous diseases. Decreased concentrations of adenine nucleotides, leaky outer and inner mitochondrial membranes, and decreased activities of respiratory chain enzymes contribute to depression of cellular energy metabolism, one of the most important consequences of mitochondrial impairment as characterized by decreased cytosolic phosphorylation potentials.

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Adenine Nucleotides Animals Calcium Signaling Electron Transport Energy Metabolism Humans Intracellular Membranes Mitochondria Mitochondrial Diseases Sepsis Journal Article Research Support, Non-U.S. Gov't Review

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Frank Norbert Gellerich, Sonata Trumbeckaite, Ying Chen, Marcus Deschauer, Tobias M ller, Stephan Zierz. Energetic depression caused by mitochondrial dysfunction.. https://pubmed.ncbi.nlm.nih.gov/12517722/

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