Multiple elements within the Xic regulate random X inactivation in mice.

Philippe Clerc; Philip Avner

doi:10.1016/s1084-9521(02)00140-4

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Multiple elements within the Xic regulate random X inactivation in mice.

Philippe Clerc·Philip Avner

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Abstract

In female mammals, the majority of the genes on one of the two X-chromosomes are silenced by a process referred to as X-chromosome inactivation. The X-inactivation center (Xic), a complex genomic region on the X-chromosome which controls this process, contains the Xist gene encoding an untranslated RNA which plays a central role in the establishment of the transcriptional repression. The Xic encrypts a sophisticated program which coordinates X inactivation with sex and embryonic development. The present article reviews our current knowledge of the regulatory elements lying within the mouse Xic and of the mechanisms underlying random X inactivation.

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Animals Dosage Compensation, Genetic Female Mice RNA, Long Noncoding RNA, Untranslated Transcription Factors Journal Article Review

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Philippe Clerc, Philip Avner. 2003. Multiple elements within the Xic regulate random X inactivation in mice.. https://doi.org/10.1016/s1084-9521(02)00140-4

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