Pathways to Parkinsonism.

Mark R Cookson

doi:10.1016/s0896-6273(02)01166-2

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Pathways to Parkinsonism.

Mark R Cookson

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Abstract

A novel gene for Parkinson's disease (PD), DJ-1, has been identified that encodes a multifunctional product with several known protein-protein interactions and effects on gene expression. Here, I outline how it is possible to construct hypotheses that place DJ-1 in different relationships to the other known PD genes, alpha-synuclein and parkin. The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD.

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Animals Disease Models, Animal Humans Intracellular Signaling Peptides and Proteins Mutation Oncogene Proteins Oxidative Stress Parkinsonian Disorders Protein Deglycase DJ-1 Protein Folding Signal Transduction Journal Article Review

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Mark R Cookson. 2003-01-09. Pathways to Parkinsonism.. https://doi.org/10.1016/s0896-6273(02)01166-2

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