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Quantitative structure-activity relationships of phenolic compounds causing apoptosis.

Corwin Hansch·Benjamin Bonavida·Ali R Jazirehi·J John Cohen·Cheri Milliron·Alka Kurup
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Abstract

A study of a variety of phenolic compounds (simple phenols, estradiol, bisphenol A, diethylstilbesterol) on their action on L1210 leukemia cells led to the formulation of the following QSAR for apoptosis:log 1/C=-3.16 Clog P+2.77 CMR-3.76n=11, r(2)=0.939, s=0.630, q(2)=0.892C is the molar concentration causing 25% apoptosis, Clog P is the calculated octanol/water partition coefficient and CMR is the calculated molecular refractivity. Our results imply the significance of characterization of the phenolic compounds with apoptotic activity and the development of new agents for cancer therapy.

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AlgorithmsAnimalsApoptosisCell LineDNADNA RepairDrug DesignFlow CytometryLeukemia L1210MicePhenolsQuantitative Structure-Activity RelationshipTumor Cells, CulturedJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Corwin Hansch, Benjamin Bonavida, Ali R Jazirehi, J John Cohen, Cheri Milliron, Alka Kurup. 2003-02-20. Quantitative structure-activity relationships of phenolic compounds causing apoptosis.. https://doi.org/10.1016/s0968-0896(02)00326-7

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