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PubMed · 12546879

High-throughput cell analysis using multiplexed array technologies.

Oren E Beske·Simon Goldbard
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Abstract

The desire for more biologically relevant data from primary screening has resulted in a dramatic increase of cell-based assays in HTS labs. Consequently, new cell-array technologies are being developed to increase the quality and quantity of data emerging from such screens. These technologies take the form of both positional and non-positional formats, each with their own advantages. Notably, screens using these technologies generate databases of high-quality data that can be analyzed in ways currently not possible. The power of cell-based assays combined with new array and analytical technologies will enable the condensation of serial drug discovery processes, thereby decreasing the time and cost of taking a hit compound into clinical trials. Here, we compare array strategies being developed towards the goal of integrating multiplexed cell-based assays into HTS.

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AnimalsBiological AssayDrug Evaluation, PreclinicalHumansProtein Array AnalysisJournal ArticleReview

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BibTeXRIS

Oren E Beske, Simon Goldbard. 2002-09-15. High-throughput cell analysis using multiplexed array technologies.. https://doi.org/10.1016/s1359-6446(02)02388-7

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