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Multiple mutations and cancer.

Lawrence A Loeb·Keith R Loeb·Jon P Anderson
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Abstract

Most human tumors are highly heterogenous. We have hypothesized that this heterogeneity results from a mutator phenotype. Our premise is that normal mutation rates are insufficient to account for the multiple mutations found in human cancers, and, instead, that cancers must exhibit a mutator phenotype early during their evolution. Here, we examine the current status and implications of the mutator phenotype hypothesis for the prognosis, treatment, and prevention of human cancers.

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Lawrence A Loeb, Keith R Loeb, Jon P Anderson. 2003-01-27. Multiple mutations and cancer.. https://doi.org/10.1073/pnas.0334858100

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