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M-DNA: a self-assembling molecular wire for nanoelectronics and biosensing.

Shawn D Wettig·Chen-Zhong Li·Yi-Tao Long·Heinz-Bernhard Kraatz·Jeremy S Lee
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Abstract

M-DNA is a complex between divalent metal ions such as Zn2+ and duplex DNA which forms at pH 8.5. Unlike B-DNA, M-DNA does not bind ethidium so that M-DNA formation can be monitored conveniently by an ethidium fluorescence assay. M-DNA was shown to be a better conductor than B-DNA by fluorometric measurements of electron transport in donor-acceptor labelled duplexes; by direct conductivity measurements of M-DNA bound between gold electrodes and by cyclic voltammetric studies on ferrocene labelled duplexes attached to gold microelectrodes. As is the case with B-DNA, M-DNA can self-assemble into a variety of structures and is anticipated to find widespread use in nanoelectronics and biosensing.

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Biosensing TechniquesDNANanotechnologyNucleic Acid ConformationJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Shawn D Wettig, Chen-Zhong Li, Yi-Tao Long, Heinz-Bernhard Kraatz, Jeremy S Lee. 2003. M-DNA: a self-assembling molecular wire for nanoelectronics and biosensing.. https://doi.org/10.2116/analsci.19.23

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