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A mild deprotection strategy for allyl-protecting groups and its implications in sequence specific dendrimer synthesis.

Dharma Rao Vutukuri·Pandi Bharathi·Zhouying Yu·Karthik Rajasekaran·My-Huyen Tran·S Thayumanavan
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Abstract

A mild deprotection strategy for allyl ethers under basic conditions in the presence of a palladium catalyst is described. Under these conditions, aryl allyl ethers can be cleaved selectively in the presence of alkyl allyl ethers. These conditions are also effective in the deprotection of allyloxycarbonyl groups. The utility of the current methodology in sequence specific dendrimer synthesis is demonstrated.

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Allyl CompoundsBenzyl AlcoholsCatalysisEthersIndicators and ReagentsMolecular StructurePalladiumStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Dharma Rao Vutukuri, Pandi Bharathi, Zhouying Yu, Karthik Rajasekaran, My-Huyen Tran, S Thayumanavan. 2003-02-07. A mild deprotection strategy for allyl-protecting groups and its implications in sequence specific dendrimer synthesis.. https://doi.org/10.1021/jo026469p

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