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Tor signalling in bugs, brain and brawn.

Estela Jacinto·Michael N Hall
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Abstract

TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.

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AnimalsDrosophila ProteinsDrosophila melanogasterHumansPhosphatidylinositol 3-KinasesPhosphotransferases (Alcohol Group Acceptor)Receptor Protein-Tyrosine KinasesSaccharomyces cerevisiae ProteinsSignal TransductionTacrolimus Binding Protein 1AJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Estela Jacinto, Michael N Hall. 2003. Tor signalling in bugs, brain and brawn.. https://doi.org/10.1038/nrm1018

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