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PubMed · 12565960

Thiophene-based vitronectin receptor antagonists.

Monica Bubenik·Karen Meerovitch·Frédéric Bergeron·Giorgio Attardo·Laval Chan
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Abstract

A series of alpha(v)beta(3) antagonists based on a thiophene scaffold were synthesized via two routes and evaluated for in vitro biological activity. We have identified several structurally similar antagonists with different selectivities towards alpha(IIb)beta(3), alpha(v)beta(5) and alpha(5)beta(1) at the cellular level. In addition, these antagonists exerted an antiangiogenic effect in the chick chorioallantoic membrane (CAM) assay.

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Angiogenesis InhibitorsAnimalsChick EmbryoChorionEndothelial Growth FactorsGuanidinesHumansIntegrin alphaVbeta3Intercellular Signaling Peptides and ProteinsK562 CellsLymphokinesOligopeptidesPlatelet Glycoprotein GPIIb-IIIa ComplexReceptors, VitronectinStructure-Activity RelationshipThiophenesVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsJournal Article

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BibTeXRIS

Monica Bubenik, Karen Meerovitch, Frédéric Bergeron, Giorgio Attardo, Laval Chan. 2003-02-10. Thiophene-based vitronectin receptor antagonists.. https://doi.org/10.1016/s0960-894x(02)00942-3

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