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PubMed · 12568334

Retrovirus molecular conjugates.

Q Zhong·J K Kolls·P Schwarzenberger
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Abstract

Retrovirus-derived vectors are currently the preferred vectors used for human gene therapy protocols. Serious safety concerns persist, however, which are specifically related to the formation of a replication-competent virus, and no synthesis method currently employed precludes its formation with certainty. For many cell types, a low transduction efficiency results in insufficient therapeutic benefit. We describe the development of a molecular conjugate system, which permits transient chemical modification of a retrovirus with polylysine. This modification not only introduces additional safety features over standard unmodified retrovirus vectors, but also provides enhanced transduction efficiency.

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AnimalsGenetic TherapyGenetic VectorsHumansPolylysineRetroviridaeTransduction, GeneticJournal Article

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Q Zhong, J K Kolls, P Schwarzenberger. 2002. Retrovirus molecular conjugates.. https://doi.org/10.1007/s000180200008

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