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PubMed · 12570864

Imino-sugar-based nucleosides.

Vern L Schramm·Peter C Tyler
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Abstract

Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-C-nucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.

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Vern L Schramm, Peter C Tyler. 2003. Imino-sugar-based nucleosides.. https://doi.org/10.2174/1568026033452465

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