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PubMed · 1257792

Complement-dependent immunoglobulin G receptor function in lymphoid cells.

J C Scornik
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Abstract

Lymphoid cells are unable to lyse antibody-coated target cells in the presence of normal immunoglobulin G (IgG), presumably because their surface receptors of IgG are blocked. However, when target cells are sensitized with antibodies and complement, IgG receptors are unblocked and cytotoxicity occurs even in the presence of normal IgG. Thus, IgG receptors may function in vivo despite the relatively high concentations of IgG in serum and interstitial fluid.

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Antigen-Antibody ComplexComplement C3Complement System ProteinsCytotoxicity Tests, ImmunologicImmunity, CellularImmunoglobulin GLymphocytesModels, BiologicalReceptors, DrugJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J C Scornik. 1976-05-07. Complement-dependent immunoglobulin G receptor function in lymphoid cells.. https://doi.org/10.1126/science.1257792

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