Single-molecule folding.

Xiaowei Zhuang; Matthias Rief

doi:10.1016/s0959-440x(03)00011-3

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PubMed · 12581665

Single-molecule folding.

Xiaowei Zhuang·Matthias Rief

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Abstract

Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individual biomacromolecules. These single-molecule approaches can directly resolve transient intermediate states and multiple reaction pathways, and thus are uniquely powerful in characterizing the complex dynamics of biological processes. Recent applications of these two techniques to the protein and RNA folding problems have led to exciting new results.

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Connectin Fluorescence Resonance Energy Transfer Macromolecular Substances Microscopy, Atomic Force Models, Molecular Motion Muscle Proteins Nucleic Acid Conformation Physical Stimulation Protein Conformation Protein Denaturation Protein Folding Protein Kinases Proteins RNA Journal Article Review

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Xiaowei Zhuang, Matthias Rief. 2003. Single-molecule folding.. https://doi.org/10.1016/s0959-440x(03)00011-3

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