On biologically conformal boost dose optimization.

M Alber; F Paulsen; S M Eschmann; H J Machulla

doi:10.1088/0031-9155/48/2/404

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On biologically conformal boost dose optimization.

M Alber·F Paulsen·S M Eschmann·H J Machulla

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Abstract

A method is described that allows the inclusion of biological imaging data in the optimization of intensity-modulated radiotherapy to produce dose boosts that conform with target subvolumes of potentially reduced radiosensitivity. The biological image (e.g. PET, fMRI, etc) is transformed into a dose efficiency distribution using a piecewise linear calibration function with a prescribed maximum boost factor. Instead of dose alone, the cost function of the optimization algorithm depends on the product of the physical dose times dose efficiency. An example case of a base-of-tongue tumour which was imaged with the hypoxia tracer fluoro-misonidazole is presented, showing the excellent capability of IMRT to produce dose distributions that conform to spatially variable dose prescriptions.

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Algorithms Imaging, Three-Dimensional Misonidazole Quality Control Radiometry Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Radiotherapy, Conformal Tomography, Emission-Computed Tongue Neoplasms Journal Article Research Support, Non-U.S. Gov't

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M Alber, F Paulsen, S M Eschmann, H J Machulla. 2003-01-21. On biologically conformal boost dose optimization.. https://doi.org/10.1088/0031-9155%2F48%2F2%2F404

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