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PubMed · 12596194

Vancomycin assembly: nature's way.

Brian K Hubbard·Christopher T Walsh
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Abstract

Antibiotics are precious resources in the fight to combat bacterial infections caused by pathogenic organisms. Vancomycin is one of the antibiotics of last resort in the treatment of life-threatening infections by gram-positive bacteria. The rules by which nature assembles the glycopeptide (vancomycin) and lipoglycopeptide (teicoplanin) antibiotics are becoming elucidated and verified: first amino acids are synthesized, then joined together and cross-linked. This knowledge opens up approaches for reprogramming strategies at the level of altered monomers, swapped assembly lines, and different post-assembly tailoring enzymes.

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Anti-Bacterial AgentsBacteriaDrug Resistance, BacterialGene Expression Regulation, BacterialGlycosylationVancomycinJournal ArticleReview

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Brian K Hubbard, Christopher T Walsh. 2003-02-17. Vancomycin assembly: nature's way.. https://doi.org/10.1002/anie.200390202

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