Slit and robo: expression patterns in lung development.

Mark A Anselmo; Sussie Dalvin; Parthak Prodhan; Katsumi Komatsuzaki; Jeremy T Aidlen; Jay J Schnitzer; Jane Y Wu; T Bernard Kinane

doi:10.1016/s1567-133x(02)00095-9

PubMed · 12609596

Slit and robo: expression patterns in lung development.

Mark A Anselmo·Sussie Dalvin·Parthak Prodhan·Katsumi Komatsuzaki·Jeremy T Aidlen·Jay J Schnitzer·Jane Y Wu·T Bernard Kinane

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Abstract

First described as an axonal guidance cue through its repulsive effect on neurons expressing its receptor Roundabout (Robo), the Slit ligand has effects on cell migration, axon branching and elongation. Indirect evidence implicates Slit and Robo in lung development. We now demonstrate that Slit-2 and Slit-3 are developmentally regulated in embryonic murine lung. Immunohistochemistry demonstrates Slit-2 and Slit-3 expression by the pulmonary mesenchyme and airway epithelium. Robo-1 and Robo-2 are also expressed by the developing mesenchyme and airway epithelium. As lung development progresses, Robo-1 and Robo-2 expression localizes to only the airway epithelium. We conclude Slit/Robo are expressed in temporo-spatially adjacent domains suggesting interactive roles in pulmonary bronchiolar development.

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Animals Drosophila Proteins Gene Expression Profiling Lung Mice Nerve Tissue Proteins Receptors, Immunologic Roundabout Proteins Journal Article Research Support, U.S. Gov't, P.H.S.

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Mark A Anselmo, Sussie Dalvin, Parthak Prodhan, Katsumi Komatsuzaki, Jeremy T Aidlen, Jay J Schnitzer, Jane Y Wu, T Bernard Kinane. 2003. Slit and robo: expression patterns in lung development.. https://doi.org/10.1016/s1567-133x(02)00095-9

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