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PubMed · 12611072

Targeting CD19 with genetically modified EBV-specific human T lymphocytes.

C Roessig·S P Scherer·A Baer·J Vormoor·C M Rooney·M K Brenner·H Juergens
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Abstract

Human Epstein-Barr virus-specific T cells were genetically modified to express chimeric receptors specific for human CD19, which is expressed on the cell surface of most B cell malignancies. The receptor-modified EBV-specific T cells can be expanded and maintained long term in the presence of EBV-infected B cells. They recognize autologous EBV-infected targets through their conventional T cell receptor, and allogeneic EBV-infected targets and tumor targets through their chimeric receptor. They efficiently lyse both EBV and CD19-positive tumor targets in the absence of background cytotoxicity against CD19-negative targets. Donor-derived EBV-specific T cells expressing chimeric anti-tumor receptors may represent a source of effector cells that could be safely administered to leukemia patients to eradicate minimal residual disease after allogeneic bone marrow transplantation.

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Antigens, CD19Gene ExpressionHerpesvirus 4, HumanHumansImmunoglobulin FragmentsImmunoglobulin GImmunotherapy, AdoptiveLeukemiaNeoplasm, ResidualReceptors, FcRecombinant Fusion ProteinsStem Cell TransplantationT-LymphocytesTransfectionJournal Article

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C Roessig, S P Scherer, A Baer, J Vormoor, C M Rooney, M K Brenner, H Juergens. 2002. Targeting CD19 with genetically modified EBV-specific human T lymphocytes.. https://pubmed.ncbi.nlm.nih.gov/12611072/

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