An evolutionary and structural perspective on T cell antigen receptor function.

Bernard Malissen

doi:10.1034/j.1600-065x.2003.00016.x

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An evolutionary and structural perspective on T cell antigen receptor function.

Bernard Malissen

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Abstract

After a brief overview of the themes and variations that occur in the family of receptors containing immunoreceptor tyrosine-based activation motifs (ITAMs), and of recent structural data on the ligand-binding subunits of these receptors, we use these data to revisit how information on the state and quality of occupancy of the binding site of the T cell antigen receptor (TCR) is conveyed to the proximal components of the TCR transduction cassette.

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Amino Acid Sequence Animals Binding Sites CD3 Complex CD4 Antigens Humans Molecular Sequence Data Protein-Tyrosine Kinases Receptors, Antigen, T-Cell Sequence Alignment Signal Transduction Tyrosine Journal Article Research Support, Non-U.S. Gov't Review

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Bernard Malissen. 2003. An evolutionary and structural perspective on T cell antigen receptor function.. https://doi.org/10.1034/j.1600-065x.2003.00016.x

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