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PubMed · 12627556

Proposed model ethical protocol for collecting DNA samples.

K M Weiss·L L Cavalli-Sforza·G M Dunston·M Feldman·H T Greely·K K Kidd·M King·J A Moore·E Szathmary·C M Twinn·North American Regional Committee of the Human Genome Diversity Project
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Blood Specimen CollectionConfidentialityCultural DiversityDNADelivery of Health CareEthics, ResearchGenetic PrivacyGenetic ResearchGenetic VariationGenetics, PopulationGuidelines as TopicHuman Genome ProjectHuman RightsHumansIndians, North AmericanInformed ConsentInternationalityOwnershipPatents as TopicPatient ParticipationResearch SubjectsSpecimen HandlingThird-Party ConsentBiomedical and Behavioral ResearchGenetics and ReproductionJournal Article

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K M Weiss, L L Cavalli-Sforza, G M Dunston, M Feldman, H T Greely, K K Kidd, M King, J A Moore, E Szathmary, C M Twinn, North American Regional Committee of the Human Genome Diversity Project. 1997. Proposed model ethical protocol for collecting DNA samples.. https://pubmed.ncbi.nlm.nih.gov/12627556/

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Therapeutic drug monitoring of tacrolimus with the dried blood spot method.

In a preliminary investigation an assay for tacrolimus based on fingerprick sampling and consecutive application as a blood spot on sampling paper has been developed. The dried blood spot was analysed by HPLC-tandem mass spectrometry. The validated range was 1-30 microg/l. Intra- and inter-assay variability for precision and accuracy was <7.5% and 15%, respectively. Tacrolimus concentrations of 24 stable out patients were compared after both blood spot sampling and conventional venous sampling. Method agreement was investigated with the methods of Passing and Bablok and Bland Altman and proved suitable for clinical use. The dried blood spot method for tacrolimus seems promising for patient monitoring.

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