B-cell commitment: deciding on the players.

Richard R Hardy

doi:10.1016/s0952-7915(03)00012-8

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B-cell commitment: deciding on the players.

Richard R Hardy

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Abstract

Considerable progress has been made over the past few years in determining the key molecular players that regulate the commitment and development of early B-lineage cells in mouse bone marrow (transcription factors, cytokines and their receptors). However, confusion remains as to the precise stages, surface phenotypes and lineage restrictions that are observed early in B-cell development. Increasingly powerful flow cytometry analysis of genetically altered animals (knockouts and transgenics) combined with sensitive functional assays may provide an answer, a "scorecard" for the cell stages.

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Animals B-Lymphocytes Cell Lineage Membrane Proteins Mice Models, Biological Proto-Oncogene Proteins Receptors, Notch Transcription Factors Wnt Proteins Zebrafish Proteins Journal Article Review

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Richard R Hardy. 2003. B-cell commitment: deciding on the players.. https://doi.org/10.1016/s0952-7915(03)00012-8

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