Apoptosis during lymphoid development.

Sue J Sohn; Arvind Rajpal; Astar Winoto

doi:10.1016/s0952-7915(03)00004-9

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Apoptosis during lymphoid development.

Sue J Sohn·Arvind Rajpal·Astar Winoto

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Abstract

Recent investigations have provided important insights into how signaling through the antigen receptors determines whether a cell survives or dies. In T cells, Grb2 and MAP kinases play essential roles in differentiating between apoptotic and survival signals. The PTEN phosphatase and Bim, a pro-apoptotic Bcl-2 family member, regulate apoptosis in both T and B cells. In B cells, antigen receptor-mediated death can be rescued by co-stimulation, in which the roles of protein kinase C and BAFF, a TNF family member, have been recently elucidated. In a recently identified mechanism of regulating inflammation, receptors such as c-mer and glycoproteins such as MFG-E8 were found to participate in the clearance of apoptotic cells.

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Animals Apoptosis Lymphocytes Mice Mice, Transgenic Models, Biological Receptors, Antigen, B-Cell Receptors, Antigen, T-Cell Signal Transduction Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Sue J Sohn, Arvind Rajpal, Astar Winoto. 2003. Apoptosis during lymphoid development.. https://doi.org/10.1016/s0952-7915(03)00004-9

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