[Xanthine derivative compounds potential activity in inflammatory process].

Gh Dănilă; Lenuţa Profire; M Costuleanu

PubMed · 12638299

[Xanthine derivative compounds potential activity in inflammatory process].

Abstract

We studied the potentially anti-inflammatory action of some new xanthine compounds, theophylline derivatives with 7-[2-hydroxy-3-(4-acetamido)-phenoxy-propyl]-8-R-1,3-dimethyl-xanthine and 8-R-1,3-bis-(1,3-dimethyl-xanthin-7yl)-2-hydroxy-propane structure substituted in 7 and 8 position. Almost all studied compounds reduced the inflammatory edema, the effect being comparable or highest theophylline. The antiinflammatory effect of theophylline intensified with the introduction in 7 position the theophylinyl radical and in 8 position the bromo, nitro, pirolidinyl, piperidinyl, morfolinyl, imidazolyl, 3,5-dimethyl-pirazolyl, 3-methyl-5-oxo-pirazolyl radicals.

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Animals Asthma Bronchodilator Agents Computer Graphics Disease Models, Animal Male Rats Rats, Wistar Theophylline Xanthine English Abstract Journal Article

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Gh Dănilă, Lenuţa Profire, M Costuleanu. [Xanthine derivative compounds potential activity in inflammatory process].. https://pubmed.ncbi.nlm.nih.gov/12638299/

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