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PubMed · 12643996

Reversing Wolbachia-based population replacement.

Stephen L Dobson
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Abstract

Genetic manipulation that reduces the competence of a vector population to transmit pathogens would provide a useful tool to complement current control strategies, which are based primarily on the reduction/exclusion of vector populations and the prophylactic/therapeutic treatment of the vertebrate host population. Genetic drive is an important component of vector population replacement strategies, facilitating the replacement of natural populations with a genetically modified population. Genetic drive is reviewed here, emphasizing strategies that would employ infections of intracellular Wolbachia bacteria as a vehicle for population replacement. Also discussed are strategies for the retarding, arresting or reversing of Wolbachia-based population replacement. These strategies are based upon altering the conditions required for transgene invasion and are a prudent safeguard, should unexpected detrimental effects become associated with transgene spread.

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AnimalsComputer SimulationCrosses, GeneticFemaleHost-Parasite InteractionsInfectious Disease Transmission, VerticalInfertilityInsectaMaleWolbachiaJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Review

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Stephen L Dobson. 2003. Reversing Wolbachia-based population replacement.. https://doi.org/10.1016/s1471-4922(03)00002-3

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