PubMed · 12645582
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Patricia McDermot. 2003. Recognizing normeperidine toxicity.. https://doi.org/10.1097/00152193-200303000-00014
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Sixty-four new indanones and thiaindanones related to donepezil were synthesized and evaluated in vitro as potential AChE inhibitors. Among them, 11 derivatives were found to inhibit the enzyme in the submicromolar range; the best compound revealed its inhibitory activity with an IC50 in the same range (0.06 microM) than the reference compound, donepezil (IC50=0.02 microM).
A case of lethal ethyl-parathion poisoning following intentional ingestion is reported. The patient presented with classical symptoms of the cholinergic hyperstimulation syndrome. Although ethyl-parathion is now prohibited in the EU, cases of this serious poisoning are still seen. The symptomatology and treatment are described.