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PubMed · 12646651

IL-4 exacerbates anaphylaxis.

Richard T Strait·Suzanne C Morris·Kristi Smiley·Joseph F Urban·Fred D Finkelman
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Abstract

We evaluated whether IL-4, a cytokine critical for inducing allergic responses, also contributes to the effector phase of allergy. Pretreatment of mice with IL-4 or the related cytokine, IL-13, rapidly and dramatically increased the severity of anaphylaxis induced by cross-linking Fc(epsilon)RI or FcgammaRIII. This effect was inhibited by endogenously produced IFN-gamma, was T cell-, B cell-, and common gamma-chain-independent, and required IL-4Ralpha and Stat6. IL-4Ralpha signaling also enhanced anaphylaxis in mice infected with a nematode parasite that stimulates IL-4/IL-13 production. IL-4 exacerbated anaphylaxis by acting synergistically with vasoactive mediators to increase vascular permeability. Synergy between IL-4 and vasoactive mediators during the effector phase of allergic inflammation may both contribute to allergic immunopathology and enhance protective immunity against gastrointestinal worms.

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Adjuvants, ImmunologicAnaphylaxisAnimalsCapillary Leak SyndromeDose-Response Relationship, ImmunologicDrug Therapy, CombinationFemaleInjections, IntravenousInterleukin-12Interleukin-13Interleukin-18Interleukin-4Leukotriene C4MaleMiceMice, Inbred BALB CMice, KnockoutMice, NudeMice, TransgenicPlatelet Activating FactorSTAT6 Transcription FactorSerotoninSignal TransductionTrans-ActivatorsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Richard T Strait, Suzanne C Morris, Kristi Smiley, Joseph F Urban, Fred D Finkelman. 2003-04-01. IL-4 exacerbates anaphylaxis.. https://doi.org/10.4049/jimmunol.170.7.3835

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