Dynamical synaptic plasticity: a model and connection to some experiments.

A Whitehead; M I Rabinovich; R Huerta; V P Zhigulin; Henry D I Abarbanel

doi:10.1007/s00422-002-0376-4

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Dynamical synaptic plasticity: a model and connection to some experiments.

A Whitehead·M I Rabinovich·R Huerta·V P Zhigulin·Henry D I Abarbanel

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Abstract

Using a modified version of a phenomenological model for the dynamics of synaptic plasticity, we examine some recent experiments of Wu et al. [(2001) J Physiol 533:745-755]. We show that the model is quantitatively consistent with their experimental protocols producing long-term potentiation (LTP) and long-term depression (LTD) in slice preparations of rat hippocampus. We also predict the outcome of similar experiments using different frequencies and depolarization levels than reported in their results.

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Action Potentials Animals Hippocampus Long-Term Potentiation Long-Term Synaptic Depression Models, Neurological Neural Pathways Neurons Nonlinear Dynamics Predictive Value of Tests Rats Reproducibility of Results Synapses Synaptic Transmission Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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A Whitehead, M I Rabinovich, R Huerta, V P Zhigulin, Henry D I Abarbanel. 2003. Dynamical synaptic plasticity: a model and connection to some experiments.. https://doi.org/10.1007/s00422-002-0376-4

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