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Selection events in directing B cell development.

J Seagal·D Melamed
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Abstract

Homeostasis in the B cell compartment (as well as in T cells) is controlled by tightly regulated selection events. Throughout their life span, B cells are subjected to selection signals determining not only developmental progression, but also maturation and survival. It is now clear that most of these signals require the expression of B cell antigen receptor (or preB receptor) with functional signaling capacity. The administration of numerous mutations into the mouse germline enabled us to identify several checkpoints along the B cell developmental pathway, and provided us with powerful experimental tools to probe for selection events regulating developmental progression. In here, we will discuss recent studies in this field.

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AnimalsB-LymphocytesHumansMiceReceptors, Antigen, B-CellStem CellsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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J Seagal, D Melamed. 2003. Selection events in directing B cell development.. https://doi.org/10.14670/hh-18.519

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