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The calculus of immunity: quantitating antigen processing.

Paul J Lehner
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Abstract

Peptide ligands destined for binding MHC class I molecules are generated by the proteasome in the cytoplasm and transported to the endoplasmic reticulum for loading onto newly synthesized class I molecules. A new study now provides a quantitative analysis of how total protein turnover in the cell relates to the efficiency of generating peptide epitopes presented by class I molecules.

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AnimalsAntigen PresentationEpitopesHistocompatibility Antigens Class IHumansLigandsModels, ImmunologicalPeptidesProtein BindingJournal ArticleReview

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Paul J Lehner. 2003. The calculus of immunity: quantitating antigen processing.. https://doi.org/10.1016/s1074-7613(03)00061-x

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