A Notch so simple influence on T cell development.

Gabriela Hernández-Hoyos; José Alberola-Ila

doi:10.1016/s1084-9521(02)00180-5

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A Notch so simple influence on T cell development.

Gabriela Hernández-Hoyos·José Alberola-Ila

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Abstract

T cell precursors undergo a series of developmental choices that progressively narrow their ability to give rise to different cell lineages. Evidence accumulated in the last few years suggests that Notch occupies a central place among the signal transduction pathways that regulate many of these choices, including the T/B, alphabeta/gammadelta and CD4/CD8 lineage decisions. Nevertheless the mechanisms by which Notch exerts its effects are not well understood, and in some cases the physiologic role is unclear. In this review we try to present succinctly the experiments and highlight the areas of controversy.

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Animals Gene Expression Regulation, Developmental Humans Membrane Proteins Receptors, Notch Signal Transduction T-Lymphocytes Thymus Gland Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Gabriela Hernández-Hoyos, José Alberola-Ila. 2003. A Notch so simple influence on T cell development.. https://doi.org/10.1016/s1084-9521(02)00180-5

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