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PubMed · 1265337

Dose related changes in tissue morphine concentration.

E F Hahn·B I Norton·J Fishman
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Abstract

Rats were injected with morphine-6(3)H diluted with increasing amounts of non-radiolabelled morphine. The entry of the isotope into the brain and various tissues was measured by combustion in a tissue oxidizer. The relative distribution of morphine between the blood and brain remained constant at about 5.5:1 over the range of doses studied (0.07 - 10.0 mg/kg). No dose related differential effects on morphine uptake were evident in central tissues, with the exception of the hypothalamus which exhibited a disproportionately greater uptake. Among the noncentral tissues, kidney and liver showed the greatest dose related increases in uptake.

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AnimalsBrainMaleMorphineOrgan SpecificityRatsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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E F Hahn, B I Norton, J Fishman. 1976. Dose related changes in tissue morphine concentration.. https://pubmed.ncbi.nlm.nih.gov/1265337/

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