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Viral versus cellular BCL-2 proteins.

J M Hardwick·D S Bellows
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Abstract

All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2. Gamma herpesviruses are associated with human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments show progress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.

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AnimalsApoptosisEvolution, MolecularGammaherpesvirinaeHerpesviridae InfectionsHumansMolecular Sequence DataPeptide HydrolasesProto-Oncogene Proteins c-bcl-2Sequence Homology, Amino AcidViral ProteinsJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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J M Hardwick, D S Bellows. 2003. Viral versus cellular BCL-2 proteins.. https://doi.org/10.1038/sj.cdd.4401133

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