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Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2.

Nadejda N Luchina·Ivan V Krivega·Elizaveta V Pankratova
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Abstract

POU homeodomain proteins are important regulators of ubiquitous as well as tissue-specific transcription. Ubiquitously expressed Oct-1 and tissue-specific Oct-2 proteins are members of the POU family and contain very similar DNA-binding POU domains. While Oct-1 is ubiquitous, Oct-2 is predominantly expressed in B cells, in activated T cells and in nervous system. Oct-1 is involved in regulation of some houskeeping genes-histone H2B, snRNAs as well as in tissue-specific regulation of immunoglobuline gene transcription and of some other genes. Here we report that novel alternatively spliced product of the human Oct-1 gene encode Oct-1L isoform with tissue-specific expression pattern, similar to Oct-2. Oct-1L differ from ubiquitously expressed Oct-1A in 5'-terminal exon (exon 1L). Analysis of nucleotide sequences from Human Genome Data Bank has located exon 1L about 108 kbp downstream ubiquitously expressed exon 1U. Amino terminus of Oct-1L show extensive similarity to amino terminus of Oct-2. We suppose, that Oct-1L may has a specific role in gene expression in lymphoid tissues and brain.

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Alternative SplicingDNA-Binding ProteinsGene Expression ProfilingHost Cell Factor C1HumansJurkat CellsOctamer Transcription Factor-1Octamer Transcription Factor-2Organ SpecificityProtein IsoformsSequence Analysis, DNATranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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Nadejda N Luchina, Ivan V Krivega, Elizaveta V Pankratova. 2003-02-03. Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2.. https://doi.org/10.1016/s0165-2478(02)00179-7

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