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New developments in migraine prophylaxis.

Marcelo E Bigal·Abouch V Krymchantowski·Alan M Rapoport
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Abstract

Migraine is a common neurological disorder that afflicts > or = 12% of the adult US population. Severe, frequent and disabling attacks require effective prophylaxis. Traditional preventive drugs such as beta-blockers, antidepressants and calcium antagonists, despite their documented efficacy, fail to offer relief for a significant proportion of migraine sufferers. Multiple threads of research over the last 15 years have led to the concept that migraine is generated from a hyperexcitable brain. This opens new perspectives in terms of preventive options, especially regarding the anticonvulsants agents. Additionally, different groups of substances, some of which nominated as non-orthodox agents, have been recently subjected to clinical trials and found to be effective. The aim of this review is to present and discuss the new options for migraine prevention.

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AcupunctureAdultAnticonvulsantsHumansMigraine DisordersRandomized Controlled Trials as TopicTreatment OutcomeUnited StatesJournal ArticleReview

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Marcelo E Bigal, Abouch V Krymchantowski, Alan M Rapoport. 2003. New developments in migraine prophylaxis.. https://doi.org/10.1517/14656566.4.4.433

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