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Normal and abnormal dental development.

Isabelle Miletich·Paul T Sharpe
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Abstract

Teeth are vertebrate organs that arise from complex and progressive interactions between an ectoderm, the oral epithelium and an underlying mesenchyme. During their early development, tooth germs exhibit many morphological and molecular similarities with other developing epithelial appendages, such as hair follicles, mammary and salivary glands, lungs, kidneys, etc. The developing mouse tooth germ, which is an experimentally accessible model for organogenesis, provides a powerful tool for elucidating the molecular mechanisms that control the development of these organs. Dentition patterning also provides a unique model for understanding how different shapes of teeth arise in different regions of the jaws. We review here the main signalling networks mediating the epithelial-mesenchymal interactions involved in tooth morphogenesis and patterning.

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AnimalsBody PatterningCell DifferentiationDNA-Binding ProteinsEpithelial CellsFibroblast Growth FactorsGenes, Tumor SuppressorHomeodomain ProteinsHumansMSX1 Transcription FactorMembrane ProteinsModels, BiologicalNeoplasm ProteinsPAX9 Transcription FactorPhosphoproteinsSignal TransductionTissue DistributionToothTooth AbnormalitiesTooth GermTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsJournal ArticleReview

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Isabelle Miletich, Paul T Sharpe. 2003-04-01. Normal and abnormal dental development.. https://doi.org/10.1093/hmg%2Fddg085

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