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Immune functions encoded by the natural killer gene complex.

Wayne M Yokoyama·Beatrice F M Plougastel
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Abstract

There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.

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Amino Acid SequenceAnimalsEvolution, MolecularHumansKiller Cells, NaturalLigandsMiceModels, ImmunologicalMolecular Sequence DataMultigene FamilyNeoplasmsPolymorphism, GeneticReceptors, ImmunologicSequence Homology, Amino AcidT-LymphocytesVirus DiseasesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Wayne M Yokoyama, Beatrice F M Plougastel. 2003. Immune functions encoded by the natural killer gene complex.. https://doi.org/10.1038/nri1055

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