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PubMed · 12669361

[Respiratory pathology associated with pneumococcus].

Paul Léophonte
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Abstract

Pneumococcal pneumonia is the leading cause of death due to infectious diseases in industrialized countries. Risk factors are mainly elderly and comorbidities. Increasing prevalence of multiresistant strains to antibiotics is a major problem for public health. Lobor consolidation remains the most frequent pattern, nevertheless less frequent than in the pre-antibiotic era; it's not significantly predictive of pneumococcal etiology. Extra-respiratory complications are more frequent in bacteremic pneumonia. Signs and symptoms are not different in HIV positive patients. There are no clinical predictive signs of penicillin-resistant pneumococcal pneumonia; nevertheless some risk factors have been identified: young age(particularly children in day-care centers), elderly patients, previous eéta-lactam treatment, nosocomial acquisition, prior hospitalization. Biologic diagnosis tools (blood cultures, sputum culture) are now completed by antigen-detection tests, particularly urinary antigen test. Most active béta-lactams on in vitro resistant strains (penicillin, amoxicillin, céfotaxime, ceftriaxone) remain the first line treatment. Mortality is near 12-15% cases among hospitalized patients, 95% of deaths concerning more than 60 years patients. Outcome is not significantly affected by drug resistance. Pneumococcal vaccination is a very important prevention among elderly and patients with underlying chronic medical conditions. Pneumococcal vaccine in France is largely ignored by general practitioners.

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Anti-Bacterial AgentsDrug Resistance, BacterialHumansPneumonia, PneumococcalPrognosisRisk FactorsEnglish AbstractJournal ArticleReview

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Paul Léophonte. 2002. [Respiratory pathology associated with pneumococcus].. https://pubmed.ncbi.nlm.nih.gov/12669361/

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