Necrosis evolution during high-temperature hyperthermia through implanted heat sources.

Paolo Badini; Peter De Cupis; Giorgio Gerosa; Massimiliano Giona

doi:10.1109/tbme.2003.808812

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Necrosis evolution during high-temperature hyperthermia through implanted heat sources.

Paolo Badini·Peter De Cupis·Giorgio Gerosa·Massimiliano Giona

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Abstract

A nonstationary model for high-temperature hyperthermic treatments is developed. The aim of this model is to describe the thermal propagation within a living tissue and to quantify its clinical effects as it regards the physiological status (necrosis) of a neoplastic body. Particular attention is turned to the description of the necrotic transition induced by heating. This leads to the introduction of a necrosis field and to an effective-medium approximation for the corresponding physiological status (vascularization, necrosis, etc.) of the exposed tissue. The resulting nonlinear, nonstationary model is applied to a multilayered spherical structure with a temperature-regulated implant, and to a clinical case of a solid liver tumor. Clinical data on the spatial extent of the necrotized region are in good agreement with model predictions.

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Computer Simulation Hot Temperature Humans Hyperthermia, Induced Liver Neoplasms Models, Biological Necrosis Neoplasms Nonlinear Dynamics Prostheses and Implants Sensitivity and Specificity Stochastic Processes Temperature Therapy, Computer-Assisted Comparative Study Evaluation Study Journal Article Validation Study

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Paolo Badini, Peter De Cupis, Giorgio Gerosa, Massimiliano Giona. 2003. Necrosis evolution during high-temperature hyperthermia through implanted heat sources.. https://doi.org/10.1109/tbme.2003.808812

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