Visualizing signals moving in cells.

Cornelis J Weijer

doi:10.1126/science.1082830

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PubMed · 12677060

Visualizing signals moving in cells.

Cornelis J Weijer

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Abstract

Cells display a highly complex spatiotemporal organization, required to exert a wide variety of different functions, for example, detection, processing, and propagation of nerve impulses by neurons; contraction and relaxation by muscle cells; movement by leukocytes; and adsorption and secretion of nutrients and metabolites by epithelial cells lining the gut. Successful execution of these complex processes requires highly dynamic information transfer between different regions and compartments within cells. Through the development of fluorescent sensors for intracellular signaling molecules coupled with improved microscopic imaging techniques, it has now become possible to investigate signal propagation in cells with high spatial and temporal resolution.

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Animals Biological Transport Cell Membrane Cell Movement Cell Nucleus Cytoplasm Cytoskeleton Diagnostic Imaging Diffusion Fluorescence Resonance Energy Transfer NADP Nucleotides, Cyclic Protein Transport Proteins Signal Transduction Journal Article Research Support, Non-U.S. Gov't Review

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Cornelis J Weijer. 2003-04-04. Visualizing signals moving in cells.. https://doi.org/10.1126/science.1082830

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