PubMed Health⌕ Search

PubMed · 12677366

Avoiding steroids in solid organ transplantation.

Abstract

The excellent results obtained today in solid-organ transplantation allow the envisaging of an improvement in long-term quality of life with a functioning graft. One way for this to be achieved is by the reduction, or even better, the avoidance, of steroid-based immunosuppression. Avoidance of steroids is indeed known to enhance the physical and psychological well being of the allograft recipient. This paper reviews the current status of steroid-free immunosuppression in renal, pancreatic, hepatic, intestinal, and cardiac transplantation.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Jan P Lerut. 2003-04-02. Avoiding steroids in solid organ transplantation.. https://doi.org/10.1007/s00147-003-0546-x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Tackling the shortage of donor kidneys: how to use the best that we have.

Shortage of kidney donor is still a major limitation for renal transplantation programs. This review focuses on the emerging practices, adopted to increase transplant activities, of expanding the criteria for donor and recipient selection without exposing the recipient to the drawbacks of a graft with inadequate nephron mass. Expanding the donor pool inevitably led to consideration for kidney transplantation of organs from older donors or from donors with hypertension, diabetes or other renal diseases. To fit the reduced performance of these suboptimal organs with the renal requirement of the recipient, selection of recipients with reduced metabolic requirements or increase of nephron mass by simultaneous transplantation of two suboptimal kidneys in the same recipient have been pursued. However, a critical aspect of both approaches is to quantify functioning nephron mass provided to the recipient by pre-transplant kidney biopsies. Morphological parameters assessed on kidney biopsies at the time of donor evaluation may serve to quantify the preserved tissue and to discriminate chronic irreversible lesions from acute changes that may account for a transiently impaired renal function in the donor, but that may recover after transplant.

Graft Survival↗