Protein-protein interactions: lessons learned.

S K Sharma; T M Ramsey; K W Bair

doi:10.2174/1568011023354191

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Protein-protein interactions: lessons learned.

S K Sharma·T M Ramsey·K W Bair

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Abstract

Protein-Protein (P-P) interactions play a pivotal role in determining cellular structure and in all cellular processes. The nature of P-P interactions is complex, and despite the large amount of research that has occurred in the field, is still poorly understood. Abnormal P-P interactions are particularly important because of their association with a variety of diseases, including cancer. This review examines P-P interactions with particular emphasis on the discovery of new anti-tumor drugs, including underlying physical forces that determine affinity and specificity and discusses classical and newer strategies used to discover inhibitors of P-P interactions, providing a number of recent cancer-related case studies and commentary.

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S K Sharma, T M Ramsey, K W Bair. 2002. Protein-protein interactions: lessons learned.. https://doi.org/10.2174/1568011023354191

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