Notch3, another Notch in T cell development.

Diana Bellavia; Antonio F Campese; Alessandra Vacca; Alberto Gulino; Isabella Screpanti

doi:10.1016/s1044-5323(03)00007-1

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Notch3, another Notch in T cell development.

Diana Bellavia·Antonio F Campese·Alessandra Vacca·Alberto Gulino·Isabella Screpanti

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Abstract

Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.

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Animals Cell Lineage Mice Models, Biological NF-kappa B Proto-Oncogene Proteins Receptor, Notch3 Receptor, Notch4 Receptors, Antigen, T-Cell Receptors, Cell Surface Receptors, Notch Signal Transduction T-Lymphocytes Thymus Gland Journal Article Research Support, Non-U.S. Gov't Review

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Diana Bellavia, Antonio F Campese, Alessandra Vacca, Alberto Gulino, Isabella Screpanti. 2003. Notch3, another Notch in T cell development.. https://doi.org/10.1016/s1044-5323(03)00007-1

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