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PubMed · 12684797

Epithelial calcium channels: from identification to function and regulation.

Joost G J Hoenderop·Bernd Nilius·René J M Bindels
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Abstract

The epithelial calcium channels TRPV5 and TRPV6 have been studied extensively in the epithelial tissues controlling Ca(2+) homeostasis and exhibit a range of distinctive properties that distinguish them from other transient receptor potential (TRP) channels. These two novel members of the superfamily of TRP channels were cloned from vitamin D-responsive epithelia: kidney, small intestine and placenta, and identified subsequently in tissues like pancreas, bone and prostate. This review addresses the unique properties of these highly Ca(2+)-selective channels and highlights their implications for the process of transepithelial Ca(2+) transport.

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AnimalsCalciumCalcium ChannelsCholecalciferolEstrogensHumansTRPV Cation ChannelsTissue DistributionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Joost G J Hoenderop, Bernd Nilius, René J M Bindels. 2003-03-27. Epithelial calcium channels: from identification to function and regulation.. https://doi.org/10.1007/s00424-003-1045-8

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