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Caveolin, caveolae, and endothelial cell function.

Philippe G Frank·Scott E Woodman·David S Park·Michael P Lisanti
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Abstract

Caveolae are 50- to 100-nm cell-surface plasma membrane invaginations observed in terminally differentiated cells. They are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking and signal transduction. The use of caveolin-1-deficient mice has provided many new insights into the roles of caveolae and caveolin-1 in the regulation of endothelial cell function. These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease.

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ArteriosclerosisCapillary PermeabilityCaveolaeCaveolinsEndothelial CellsEndothelium, VascularHemorheologyMacromolecular SubstancesNeovascularization, PhysiologicNitric Oxide SynthaseNitric Oxide Synthase Type IIISignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Philippe G Frank, Scott E Woodman, David S Park, Michael P Lisanti. 2003-04-10. Caveolin, caveolae, and endothelial cell function.. https://doi.org/10.1161/01.atv.0000070546.16946.3a

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