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PubMed · 12691660

Parkin: a multipurpose neuroprotective agent?

Mel B Feany·Leo J Pallanck
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Abstract

An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal dysfunction, Pael-R accumulation, and kainate-induced excitotoxicity. These findings suggest a central role for parkin in maintaining dopaminergic neuronal integrity and strengthen the link between AR-JP and the more common sporadic form of Parkinson's disease.

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AnimalsHumansLigasesNeuronsParkinson DiseaseUbiquitin-Protein LigasesJournal Article

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Mel B Feany, Leo J Pallanck. 2003-04-10. Parkin: a multipurpose neuroprotective agent?. https://doi.org/10.1016/s0896-6273(03)00201-0

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