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PubMed · 12696902

Self-sorting: the exception or the rule?

Anxin Wu·Lyle Isaacs
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Abstract

In this paper, we pose the question of whether self-sorting in designed systems is exceptional behavior or whether it is likely to become a more general phenomenon governing molecular recognition and self-assembly. To address this question we prepared a mixture comprising two of Davis' self-assembled ionophores, Rebek's tennis ball and calixarene tetraurea capsule, Meijer's ureidopyrimidinone, Reinhoudt's calixarene bis(rosette), and two molecular clips in CDCl(3) solution and observed the behavior of this ensemble by (1)H NMR. As hypothesized, high-fidelity self-sorting behavior was observed. The influence of several key variables-temperature, concentration, equilibrium constants, and the presence of competitors-on the fidelity of self-sorting is described. These results show that self-sorting is neither the exception nor the rule. They suggest, however, that the subset of known molecular aggregates that exceed the criteria required for thermodynamic self-sorting is larger than previously appreciated and potentially quite broad.

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Binding, CompetitiveBiomimetic MaterialsCalixarenesHydrogen BondingIonophoresKineticsMacromolecular SubstancesMagnetic Resonance SpectroscopyPyrimidinonesTemperatureUreaJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Anxin Wu, Lyle Isaacs. 2003-04-23. Self-sorting: the exception or the rule?. https://doi.org/10.1021/ja028913b

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