BRCA proteins and DNA damage checkpoints.

Zhenkun Lou; Junjie Chen

doi:10.2741/1127

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BRCA proteins and DNA damage checkpoints.

Zhenkun Lou·Junjie Chen

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Abstract

BRCA1 and BRCA2 are frequently mutated in breast cancer patients, responsible for the majority cases of familial breast cancer. Through genetic and biochemical analysis, the function of BRCA1 and BRCA2 is emerging. This review examines recent progresses in understanding the roles of BRCA proteins in DNA damage checkpoint control and how they are regulated in response to DNA damage

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Animals BRCA1 Protein BRCA2 Protein Cell Cycle DNA Damage Humans Phosphorylation Journal Article Review

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Zhenkun Lou, Junjie Chen. 2003-05-01. BRCA proteins and DNA damage checkpoints.. https://doi.org/10.2741/1127

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