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PubMed · 12706997

Replication of human hepatitis delta virus: recent developments.

John M Taylor
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Abstract

In a natural setting, hepatitis delta virus (HDV) is only found in patients that are also infected with hepatitis B virus (HBV). In hepatocytes infected with these two viruses, HDV RNA genomes are assembled using the envelope proteins of HBV. Since 1986, we have known that HDV has a small single-stranded RNA genome with a unique circular conformation that is replicated using a host RNA polymerase. These and other features make HDV and its replication unique, at least among agents that infect animals. This mini-review focuses on advances gained over the last 2-3 years, together with an evaluation of HDV questions that are either unsolved or not yet solved satisfactorily.

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Gene SilencingGenome, ViralHepatitis DHepatitis Delta VirusHumansRNA, ViralVirus ReplicationJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

John M Taylor. 2003. Replication of human hepatitis delta virus: recent developments.. https://doi.org/10.1016/s0966-842x(03)00045-3

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