The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex.

E R Podack; W P Kolb; H J Muller-Eberhard

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PubMed · 1270802

The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex.

E R Podack·W P Kolb·H J Muller-Eberhard

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Abstract

The membrane attack complex of complement (C5b-9) is identical in composition regardless of which pathway of activation was instrumental in its formation. Band V protein was consistently a subunit of the soluble complex. Since band V protein is not required for complement-dependent cytolysis, it probably represents a membrane site equivalent in serum of the nascent C5b-9 complex.

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Centrifugation, Density Gradient Complement C5 Complement C6 Complement C7 Complement C8 Complement C9 Complement System Proteins Electrophoresis, Polyacrylamide Gel Humans Journal Article Research Support, U.S. Gov't, P.H.S.

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E R Podack, W P Kolb, H J Muller-Eberhard. 1976. The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex.. https://pubmed.ncbi.nlm.nih.gov/1270802/

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