PubMed · 1271167
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P S Lietman. 1976. Editor's column: Commentary: clotrimazole.. https://doi.org/10.1016/s0022-3476(76)81164-x
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A novel triiodide ion-selective electrode based on a clotrimazole-triiodide ion pair as a membrane carrier was prepared. It has a linear response to triiodide from 8 x 10(-6) to 5 x 10(-3) M with a slope of -68.9 mV per decade and a detection limit of 5 x 10(-6) M. The electrode response is independent of the pH of the solution in the pH range 2-9. It has a very short response time and can be used for at least 3 months without any considerable divergence in the potentials. The proposed sensor revealed very good selectivities for I3- over a variety of other anions. It was used as an indicator electrode in the potentiometric titration of triiodide ions and in an indirect potentiometric determination of clotrimazole in pharmaceutical preparations.
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By means of linear sweep voltammetry the electrode processes of imidazole, clotrimazole and ketoconazole was studied. The methods of determination of clotrimazole and ketoconazole in substance and ketoconazole in tablets was elaborated.